Learning objectives
Provide knowledge about the nature of toxic effects of xenobiotics. Provide the general principles of risk assessment
Knowledge and understanding applied skills
1) To apply the knowledge of the mechanisms of action of xenobiotic to define their toxicological activity and relayed risk
Judgment autonomy
1) To evaluate the validity of results deriving from the risk assessment proces in independent manner
Communicative Skills
1) Possess the ability to synthesize information and effectively communicate it to specialists and non-specialists.
Learning Skills
1) Develop skills and methodology that will allow you to study in a highly indipendent way.
2) Updating the knowledge through the consultation of scientific databases
Prerequisites
NO
Course unit content
toxic action of xenobiotics and the main regulatory aspects; epidemiology. Food and food supplement contaminants
Full programme
General Section
· General principles of toxicology.
· Mechanisms of toxicity. Toxicity test
· Biotransformation of xenobiotics.
· Carcinogenesis, teratogenesis, mutagenesis.
· Experimental toxicology, epidemiology and toxicological risk assessment.
Special section:
· food and nutrition Toxicology, Food Additives and Contaminants. Major food supplement contaminants. Regulatory agencies.
Antiobesity and antidiabetic drugs, mechanisms of action and toxicity
Bibliography
teacher's slides
-ERNEST HODGSON: “Tossicologia Moderna”, EdiSES
-CASARETT & DOULL’S: "Tossicologia: fondamenti dell’azione delle sostanze tossiche", Ed. EMSI, Roma.
-W.A. HAYES: "Principles and Methods of Toxicology", III Edition, Raven Press.
Teaching methods
The lessons will be mainly frontal. Class attendance is not mandatory. The slides used to support lessons, as an integral part of the teaching material, will be provided directly to the students and uploaded on the Elly platform.
Assessment methods and criteria
Written examination with short and extended open questions to be taken via PC on the ELLY platform as follows:
- No. 6 questions requiring a very short open-ended response (about 1-5 words),
- No. 2 questions requiring extended open-ended response.
Rating scale: 0-30
Weights and evaluation criteria:
Short answer questions: 0 to 3 points per question. Extended response questions: 0 to 6 points per question.
A minimum of 11 points in short answers and a minimum of 7 points in extended answers must be obtained to pass the exam.
Other information
NO
2030 agenda goals for sustainable development
3
