Learning objectives
The course is aimed to know and understand the fundamental principles of toxicity from drugs and xenobiotics. The student will have to learn the basics of toxicokinetics and toxicodynamics, and the cellular targets of the toxic action of drugs. The course will illustrate the main types of toxicity in relation to the temporal development of the effects and the main toxic actions of drugs. The contents will be chosen to better understand the concept of the therapeutic index of the active ingredients used in therapy, as well as preventive measures to limit adverse drug reactions.
Prerequisites
Knowledge of basic disciplines (Anatomy, Physiology, Istology, Bichemistry, General Pathology).
Course unit content
General toxicology
Full programme
General concepts of toxicology.
Type of toxic actions and factors influencing drug toxicity.
Toxicokinetics, toxicodynamics and toxicogenetics; importance of toxicology in the development of new drugs and therapy. Concept of Therapeutic index.
Molecular mechanisms of toxicity
Notes on organ toxicity from drugs, adverse drug reactions.
Main molecules commonly responsible for adverse reactions.
Therapeutic drug monitoring.
Toxicity from pesticides, phytotherapeutics and main xenobiotics (metals, hydrocarbons, biphenyls, etc.).
Other toxicology topics will be acquired by the student in the Occupational Medicine Course, where topics more specifically related to xenobiotic toxicology will be covered.
Bibliography
Rang, Dale et al., Pharmacology - Elsevier; Katzung: Pharmacology (last ed.); Goodman and Gilman: The pharmacological basis of therapeutics (last ed.)
Teaching methods
Ex-cathedra lectures
Assessment methods and criteria
Oral exam (together with Special Pharmacology).
In case of the persistence of the health emergency, the exams will be
conducted remotely, as follows: remote oral questions, through the Teams platform (guide http://selma.unipr.it/).
Students with SLD / BSE must first contact Le Eli-che: support for students with disabilities, D.S.A., B.E.S. (https://sea.unipr.it/it/servizi/leeli-
che-supporto-studenti-con-disabilita-dsa-bes).
Other information
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2030 agenda goals for sustainable development
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